7/25/2023 0 Comments 2021 pathfinder![]() ![]() This project aims to develop a virtual reality (VR)-based simulation for training personnel on conducting aerial reconnaissance with the purpose of identifying, locating, and characterizing hazardous debris and spills. Repurposing a Commercial Off-the-Shelf Flight Simulator to Support Aerial Reconnaissance Training Thus, this project aims to advance the risk assessment of neurotoxic chemicals by measuring markers (proteins and gene expressions) in rats’ cerebrospinal fluid (CSF) using targeted Nanostring technology to determine risk levels associated with different doses. This project could provide actionable data on safeguarding human health from neurotoxic pollutants like heavy metals and pesticides more quickly and help set risk thresholds for data poor chemicals in months rather than years, allowing research efforts to focus on the most toxic environmental chemicals. Setting safety thresholds for the thousands of chemicals to which people are regularly exposed takes years. Next Generation Risk Assessment of Neurotoxic Chemicals This work could allow researchers to perform microbial interventions that will help identify factors that could protect against damage from pollutant-induced lung inflammation. Thus, this study aims to characterize the complete microbial population of the respiratory system along with its resident immune population and identify the response of the lung microbiome to inhaled air pollutants. However, the respiratory microbiome has yet to be appreciated in the risk assessment of air pollutants. New studies have shown that the lung harbors all microbial populations, which all seem to respond dynamically to disease and changes in the environment. The Respiratory Microbiome Be lungs at the Forefront of Inhalational Toxicology This would transform our ability to promote public health and meet legislative mandates for protecting vulnerable populations. This work could help ORD consider susceptible/vulnerable populations in inhaled chemical testing while also supporting EJ efforts to reduce in vivo animal testing. Thus, this project aims to integrate susceptibility and vulnerability into in vitro NAMs as a first step toward incorporating environmental justice into in vitro inhaled chemical testing. ![]() The development of in vitro approaches for inhaled chemical testing provides an opportunity to consider EJ-related communities in environmental chemical decision making. Low-income, minority, and otherwise vulnerable populations experience disproportionately high environmental chemical and pollutant exposures. Integration of Environmental Justice into NAMs for Inhaled Chemical Testing This project aims to better understand how participation in EPA’s EJ Academy supports individuals who want to contribute to environmental justice initiatives that address complex socio-environmental challenges and help developers across the Agency understand the impacts of their work and inform strategies. One domain with a range of complex issues is the field of environmental justice (EJ). Learn more about Pathfinder Innovation Projects.īut How Do We Know it Works? Increasing Capacity for Understanding Outcomes Associated with EPA's EJ AcademyĪccurately understanding the outcomes of EPA programs and tools is a challenge because they are often related to highly complex socio-environmental issues that impact human and ecological health. Below is information on the 2021 awarded PIP projects. ?" The internal competition provides staff time and seed funding in pursuit of high-risk, high-reward research ideas. Pathfinder Innovation Projects (PIPS) challenge EPA scientists to answer the question, "Wouldn't it be amazing if we could. Congratulations to this year's PIPs winners! ![]()
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